3DP has gained a lot of attention as a unique pharmaceutical manufacturing process because of its particular benefits over traditional production approaches, such as the ability to achieve desirable and variable medicinal doses. Three-dimensional printing (3DP) technology, also known as additive manufacturing (AM), is based on computer-aided design (CAD) and is capable of selectively placing printing materials layer-by-layer to generate pieces to assemble a final product with predesigned geometry. It is estimated that approximately 1 in 25 adults has swallowing problems. FDFs can also be useful for patients who have swallowing difficulties (dysphagia). FDFs are suitable for paediatric and geriatric patient populations, where the difficulty of swallowing larger oral dosage forms is eliminated. In conclusion, only chitosan micro-ribbons created a network of hydrophilic channels within the films, which allowed faster disintegration time at considerably lower concentrations.įast-dissolving oral films (FDFs) are a new way to boost consumer acceptance since they dissolve quickly in the mouth, and usually are administered without water. Cellulose micro-fibres delayed disintegration of PVA mesh films to 108.66 ± 3.68 s at 1% w/ w. Furthermore, mesh FDFs containing only 1% chitosan micro-ribbons disintegrated in distilled water within 40.33 ± 4.64 s, while mesh FDFs containing only 7% croscarmellose disintegrated in 55.33 ± 2.86 s, and croscarmellose containing films showed signs of excipient scorching for PVA polymer. The filaments were not suitable for printing at higher concentrations of chitosan micro-ribbons and cellulose micro-fibres. Both chitosan micro-ribbons and cellulose micro-fibres improved filament mechanical properties at 1% w/ w concentration in terms of flexibility and stiffness. FDFs were printed with plain or mesh patterns at temperatures of 200 ☌ (PVA) or 180 ☌ (PVP). At 130 ☌, filaments containing polyvinylpyrrolidone (PVP) and paracetamol were also created. Filaments containing polyvinyl alcohol (PVA) and paracetamol as model drug were manufactured at 170 ☌. This work investigated whether adding chitosan micro-ribbons or cellulose microfibres will achieve desired FDFs by fused deposition modelling 3DP. However, mechanical properties of the films may not be desirable when certain excipients are used. One up, would that create this error? The only way I get the site to work is by leaving one of the host header values as blank, and then it finds it but unfortunately it still only shows the ip address of my server.Three-dimensional printing (3DP) allows production of novel fast dissolving oral films (FDFs). I have three host header valuesĪll tcp 80 Value: Blank, If I remove the Blank one I get a blank page with : In BOLD Bad Request (Invalid Hostname) I have little to no knowledge of IIS 6 and it's possible that I deleted the site orginally and then set a new My server but for some reason, my server then states that the object has been moved? I'm hosting many sites all using host header values to redirect them and they all work except this one. X-Powered-By: ASP.NET Content-Length: 14836 Content-Type: text/html Set-Cookie: ASPSESSIONIDQACQDCAD=GFIFMIFAMMBLOIJMAFPIIJCC path=/ Cache-control: private Destination URI: As you can see the host header value is correct at entry to HEAD / HTTP/1.1 Connection: Keep-Alive HOST: 81.137.140.145 User-Agent: Mozilla/5.0 (compatible Googlebot/2.1 +) Accept: */* SERVER RESPONSE: 200 OK Date: Tue, 11:36:34 GMT Server: Microsoft-IIS/6.0 REQUESTING: HEAD / HTTP/1.1 Connection: Keep-Alive HOST: User-Agent: Mozilla/5.0 (compatible Googlebot/2.1 +) Accept: */* SERVER RESPONSE: 302 Object moved Date: Tue, 23 DecĢ008 11:36:30 GMT Server: Microsoft-IIS/6.0 Location: Content-Length: 142 Content-Type: text/html Set-Cookie: ASPSESSIONIDSQSTSTCD=ALOEBNDANKNHLBJDPDHFJFEO path=/ Cache-control: private Redirecting to. Hi I have run a Host check on a site that is on my server and I get this response: Code: URI Valet Report for Requested: 3 03:36:39 User Agent: Mozilla/5.0 (compatible Googlebot/2.1 +) Server Headersĭetails 1.
0 kommentar(er)
